Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2012        Go!    
 
 
November 24, Friday 2017 12:17 AM       

       HEADLINES: Actress attack case: Police to request for special court for trial                                              Dileep tried to defame actress even after attack                                              Murugan’s death: Six doctors become accused                                              Saesendran shouldn’t be minister again: Chennithala                                              Ministerial-level team heads to Munnar to solve land issues                                              Cong, Hardik deceiving each other on Patel reservation: Jaitley                                              Saeed's release order: Pak 'hoodwinking' global community                                              Will not modify Govt order banning pet coke, furnace oil: SC                                              Chennai: Student's suicide triggers violence in Sathyabama University                                              People have cancer because of their sins: Assam Health Minister                                              Zimbabwe's ex-VP Mnangagwa to be sworn in as President                                              Russia, Iran, Turkey agree to hold Syrian 'congress'                                              SE Asia, S Asia beginning to emerge as regional powers: Australia FM                                              Tibet wants to stay with China, seeks development: Dalai Lama                                              Here's when Federer felt insulted                                              BCCI has lost its reputation: Anurag Thakur                                              Hong Kong Open: Sindhu advances to quarter finals                                              Virat Kohli slams poor planning by BCCI ahead of SA tour                                              Kaumudi Facebook
       SCI&TECH Next Article: WhatsApp launches video calling to take on Google Duo, Skype  
       Why wounds take longer to heal with age decoded
 
         Posted on :19:19:47 Nov 18, 2016
   
A A
       Last edited on:19:19:47 Nov 18, 2016
         Tags: Why wounds, heal with age decoded
 
NEW YORK: Wounds take longer to heal in older people because of disruption in communication between skin cells and the immune system with age, a new study has found. Researchers explored this physiological puzzle by examining molecular changes in ageing mouse skin.
 
"Within days of an injury, skin cells migrate in and close the wound, a process that requires coordination with nearby immune cells," said Elaine Fuchs from the Rockefeller University in the US. "Our experiments have shown that, with ageing, disruptions to communication between skin cells and their immune cells slow down this step," said Fuchs.
 
"This discovery suggests new approaches to developing treatments that could speed healing among older people," Fuchs added. Whenever a wound occurs, the body needs to repair it quickly to restore its protective skin barrier. Both skin cells and immune cells contribute to this elaborate process, which begins with the formation of a scab.
 
New skin cells known as keratinocytes later travel in as a sheet to fill in the wound under the scab. Researchers focused on this latter step in healing in two-month-old versus 24-month-old mice—roughly equivalent to 20- and 70-year-old humans.
 
They found that among the older mice, keratinocytes were much slower to migrate into the skin gap under the scab and as a result, wounds often took days longer to close. Wound healing is known to require specialised immune cells that reside in the skin.
 
The researcher's new experiments showed that following an injury, the keratinocytes at the wound edge talk to these immune cells by producing proteins known as Skints that appear to tell the immune cells to stay around and assist in filling the gap. In older mice, the keratinocytes failed to produce these immune signals.
 
To see if they could enhance Skint signalling in older skin, the researchers turned to a protein that resident immune cells normally release after injury. When they applied this protein to young and old mouse skin tissue in a petri dish, they saw an increase in keratinocyte migration, which was most pronounced in the older skin. In effect, the old keratinocytes behaved more youthfully.
 
The scientists hope the same principle could be applied to developing treatments for age-related delays in healing. "Our work suggests it may be possible to develop drugs to activate pathways that help ageing skin cells to communicate better with their immune cell neighbours, and so boost the signals that normally decline with age," said Fuchs. The study appears in the journal Cell. 
A A
       SCI&TECH
Next Article: WhatsApp launches video calling to take on Google Duo, Skype
 
 
SCI&TECH HEADLINES
How breastmilk protects babies from food allergy decoded  
Stars among the oldest in our galaxy discovered  
Apple delays release of smart speaker - HomePod  
Owning a dog may add years to your life  
'Textisms' actually add meaning to written words  
Sugar may heal wounds, says study  
Heart-stopping sex? It's rare  
Over 1.3 lakh Indians 'book ticket' to Mars  
China all set to make first contact with aliens  
Greenland Ice sheet could be losing mass, says study  
'Flying taxis' could be a thing by 2020  
When art comes to the rescue of depressed patients  
Here's a mechanism that can help you get rid of bad memories  
2017 ozone hole smallest since 1988: NASA  
Marijuana can dull the brain in some HIV patients  
We use lesser brainpower than thought  
You can soon delete 'sent messages' on WhatsApp  
There is a connection between nose and emotions  
75% of pet reptiles die within a year: Study  
Gamma rays will reach beyond limits of light: Researchers  
Suicide molecules may help combat cancer: Study  
Aspirin a day may keep liver cancer away  
Clearing the myths about osteoporosis  
Stress as unhealthy as junk food  
Planet Nine does exist in solar system: NASA  
 
Do you think that all charges against actor Dileep under various IPC sections will stand in the court?
yes
 
no
 
no opinion
 
 
 
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]kaumudi.com
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy